iOnctura

About

Our mission is to develop high impact, low disruption therapies that extend healthspan. We do this by disrupting the dynamic interplay at the heart of the tumor-stroma-immune interface.

We target neglected and hard to treat cancers. Conventional therapies for these cancers often come with unwelcome side effects that can be as punishing as the disease itself. Challenging the status quo, we develop more effective, less toxic treatments.

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Our pipeline

We are finding the key to unlock challenging tumors burdened by stroma and immune mediated resistance.

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    Roginolisib IOA-244

    The first allosteric modulator of PI3Kδ, with a unique chemical structure and binding mode.

    Allosteric modulation changes the 3D structure of a protein thereby affecting its activity. The phosphatidylinositol 3-kinase (PI3K) signalling pathway is one of the most commonly dysregulated pathways in cancer. PI3Kδ is one of four isoforms of the catalytic subunit of PI3K kinase. Whilst its expression is normally restricted to immune cells such as regulatory T cells and myeloid-derived suppressive cells, some cancers express high levels of PI3Kδ which acts to promote tumor growth and survival.

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    Cambritaxestat IOA-289

    The only autotaxin inhibitor currently in clinical development to treat cancer.

    It distinctively inhibits both the catalytic and the chaperone activities of the enzyme. Autotaxin (ATX) is an extracellular enzyme that generates and transports lysophosphatidic acid (LPA). LPA is a bioactive phospholipid that stimulates the proliferation, migration and survival of many cell types and has been implicated in a wide range of diseases, including cancer.

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    IOA-359

    A novel small molecule TGF-β pathway inhibitor.

    Activation of the transforming growth factor beta (TGF-β) signaling pathway in tumors correlates with tumor aggressiveness, immune escape and resistance to therapy.

Putting patients first

  • People Walking Along A Path

    “The impact of Roginolisib on my life has been immeasurable. Not only am I still here, but I’m still able to enjoy all of the things I love doing, like being active with my friends and family.”

    Clinical trial patient, Europe
  • Michele Maio

    “Patients tolerated roginolisib very well and allowed the drug to be given for several months resulting in longer than historically expected overall survival.”

    Professor Michele Maio, Università Degli Studi Di Siena
  • Professor Dr Armando Santoro New

    “I have been very impressed with the safety profile of roginolisib and patients taking this drug have been able to live longer than expected.”

    Professor Dr Armando Santoro, Humanitas Milan

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