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What’s Next For Cambritaxestat?
Industry Insight
Realizing the potential of PI3Kδ inhibitors in peripheral T-cell lymphomas
Industry Insight
iOnctura Expands Roginolisib Trials to the US
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iOnctura Enhances Board to Accelerate Growth and Innovation
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Addressing Drug Resistance in Non-Small Cell Lung Cancer
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Scientific innovation in uveal melanoma
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Opportunities and challenges in oncology immunotherapy
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Reflections from our CEO
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Pancreatic cancer – our commitment to scientific advances
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A bold new era in global cancer drug discovery
Industry Insight
A note from our CEO
Industry Insight
Realising the potential of autotaxin therapy in cancer
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Data & publication
Autotaxin inhibitor IOA-289 reduces gastrointestinal cancer progression in preclinical models
Data & publication
Autotaxin inhibition with IOA-289 decreases breast tumor growth in mice whereas knockout of autotaxin in adipocytes does not
Data & publication
TLR-X (IOA-359) attenuates steatosis and fibrosis in a preclinical NASH model
Data & publication
IOA-289, an orally available type IV autotaxin inhibitor, ameliorates steatosis and fibrosis in a progressive preclinical murine NASH model
Data & publication
Patient derived tumor cells identify mechanistically rational combinations for the PI3Kδ inhibitor roginolisib in solid and hematologic malignancies
Data & publication
Highly selective allosteric modulator of the phosphoinositide 3-kinase data (PI3Kδ) roginolisib (IOA-244) in a dose escalation study of patients with refractory/relapsed follicular lymphoma (FL)
Data & publication
First-in-human (FIH) phase I dose escalation study (part A) of the first oral allosteric modulator of phosphoinositide 3-kinase inhibitor delta (PI3Kδ) roginolisib in patients with advanced cancer and dose confirmation in uveal melanoma (part B)
Data & publication
Characterization and translational development of IOA-289, a novel autotaxin inhibitor for the treatment of solid tumors
Press release
iOnctura to present research at leading scientific conferences in June 2023
Press release
Peer-reviewed translational research paves the way for first-in-class autotaxin inhibitor IOA-289 in cancer
Press release
iOnctura expands pipeline and receives development grant from Health Holland and KWF
Data & publication
IOA-244 is a non–ATP-competitive, highly selective, tolerable PI3K delta inhibitor that targets solid tumors and breaks immune tolerance
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