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Scientific innovation in uveal melanoma
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Opportunities and challenges in oncology immunotherapy
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Reflections from our CEO
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Pancreatic cancer – our commitment to scientific advances
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A bold new era in global cancer drug discovery
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A note from our CEO
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Realising the potential of autotaxin therapy in cancer
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PI3Kδ inhibitors offer serious promise in solid tumors
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Emerging therapies offer hope for uveal melanoma patients
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Data & publication
Long-term safety evaluation of roginolisib (formerly IOA-244), a highly selective phosphoinositide 3-kinase inhibitor delta (PI3Kδ), in a Phase I First in Human (FIH) study
Press release
iOnctura announces publication of pioneering research describing the unique biological features of roginolisib
Data & publication
Characterization of the non-ATP competitive PI3Kδ inhibitor IOA-244 in lymphoma models: from single agent to combination screen and clinical investigation
Press release
iOnctura provides development update on first-in-class semi-allosteric PI3Kδ inhibitor program
Press release
iOnctura awarded EUR17.5 million funding from the EIC accelerator for clinical development of novel pancreatic cancer therapy
Press release
iOnctura initiates Phase Ib pancreatic cancer trial of next-generation autotaxin inhibitor IOA-289
Data & publication
Safety and clinical activity of IOA-244, a highly selective phosphoinositide 3-kinase inhibitor delta (PI3Kδ), in a Phase I first in human (FIH) study (study part A)
Data & publication
IOA-244 is a non-ATP-competitive, highly-selective, tolerable phosphoinositide-3-linase delta inhibitor that directly targets solid tumors and breaks immune tolerance
Data & publication
Non-ATP competitive inhibition of PI3δ with IOA-244 shows anti-lymphoma activity
Press release
iOnctura expands Advisory Board
Data & publication
Safety, pharmacokinetic (PK), pharmacodynamic (PD) and activity of the highly selective phosphoinositide 3-kinase inhibitor delta (PI3Kδ) inhibitor IOA-244 in patients with follicular lymphoma (FL)
Data & publication
First-in-human (FIH) phase I study of the highly selective phosphoinositide 3-kinase inhibitor delta (PI3Kδ) inhibitor IOA-244 in patients with advanced cancer
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